Audit 407225

The accompanying schedule of expenditures of federal awards (the “Schedule”) includes the federal award activity of Cold Spring Harbor Laboratory (the “Laboratory”) under programs of the federal government for the year ended December 31, 2025 and is prepared on the accrual basis of accounting. The information in this Schedule is presented in accordance with the requirements of Title 2 U.S. Code of Federal Regulations Part 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards (Uniform Guidance). Because the Schedule presents only a selected portion of the operations of the Laboratory, it is not intended to and does not present the financial position, change in net assets, or cash flows of the Laboratory. All of the Laboratory’s grants are categorized within the research and development cluster. The subcategories delineated in the accompanying schedule of expenditures of federal awards are utilized by the Laboratory for its internal reporting.

Expenditures reported on the Schedule are reported on the accrual basis of accounting. Such expenditures are recognized following the cost principles contained in the Uniform Guidance, wherein certain types of expenditures are not allowable or are limited as to reimbursement. Negative amounts represent adjustments to expenditures reported in prior years in the normal course of business. The Laboratory has not elected to use the 10% de minimis indirect cost rate as allowed under the Uniform Guidance as indirect cost allowances recovered under government grants are based on an approved indirect cost rate negotiated with the cognizant government granting agency.